News – 16 Nov 2017

Novel antibodies against a ground-breaking new target for the treatment of Cardiovascular Fibrosis developed by Enleofen Bio, with support from Abzena, featured in ‘Nature’ article

Cambridge, UK and Singapore, 14 November 2017 – Abzena plc (AIM: ABZA, ‘Abzena’), the life sciences group providing services and technologies to enable the development and manufacture of biopharmaceutical products, works with Enleofen Bio Pte Ltd (‘Enleofen Bio), to develop first-in-class antibody therapeutics for the treatment of fibrotic human diseases.

The Founders of Enleofen Bio discovered that inhibiting Interleukin 11 (IL11) prevents fibrosis through a wide range of pathways, putting it at the very centre of the fibrotic process. This breakthrough research was published today in Nature, leading scientific journal.

Enleofen Bio has developed a wide range of potent IL11 inhibitors and its fully human antibody development program is being advanced with the use of Abzena’s Composite CHO™ cell line technology. Enleofen Bio may in the future opt to progress with large scale manufacturing at Abzena’s San Diego facility.

Abzena will also support Enleofen Bio through the development of alternative strategies to block IL11 signalling. Abzena’s wide range of protein engineering technologies will help to translate findings from successful proof-of-concept studies in preclinical models of disease to the clinic.

Enleofen is currently investing proceeds from a successful Series A fundraising into the development of novel fibrosis treatments. Enleofen has an exclusive licence to a comprehensive suite of patent applications covering IL11’s role in fibrosis and a range of products to treat fibrosis.

Link to Abzena article